Dementia in individuals with severe hypercholesterolemia: Korean nationwide cohort study

Abstract Background Dementia risk and benefit of lipid lowering in individuals with severe hypercholesterolemia has not been well studied. The aim this study was to evaluate the dementia effect population using nationwide cohort. Methods This performed National Health Insurance Service database Korea. Among who took health check-up were followed-up, 1,584,401 enrolled analyzed. Study categorized three groups according LDL-C levels, >260, 225–259, 190–224 mg/dL groups, a control group (<160 mg/dL). Risks incident (all dementia, Alzheimer's disease, vascular dementia) compared. In subgroup new statin users, statins further analyzed post-treatment levels (<70, 70–99, 100–129, >130 Results median follow-up 6.1 years, all occurred up 5.41/1000 person-year hypercholesterolemia. Adjusted hazard ratios (aHRs) ranged from 1.05 1.34 (p=0.023) dependent categories. disease developed 4.94/1000 aHRs 1.04 1.38 (p=0.040) same pattern dementia. Vascular 0.59/100 1.03 1.57 without significant difference 6.2 years 0.69 0.92 for 0.74 0.53 1.15 levels. However, significantly related Conclusions newly showed elevated particularly patients active on neurological needs be proven by studies. Funding Acknowledgement Type funding sources: Other. Main source(s): Korean Society Lipid Atherosclerosis; Research Foundation Korea